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Rapid microwave-assisted solid phase peptide synthesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry. (Organic Pharmaceutical Chemistry)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry.
2002 (English)In: Synthesis (Stuttgart), ISSN 0039-7881, E-ISSN 1437-210X, no 11, 1592-1596 p.Article in journal (Refereed) Published
Abstract [en]

A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides. Optimized conditions for a variety of coupling reagents are reported. Peptides were obtained rapidly (1.5-20 min) and without racemization.

Place, publisher, year, edition, pages
2002. no 11, 1592-1596 p.
National Category
Organic Chemistry
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URN: urn:nbn:se:uu:diva-64335DOI: 10.1055/s-2002-33348OAI: oai:DiVA.org:uu-64335DiVA: diva2:92246
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Gogoll, Adolf

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