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Duodenal defence mechanisms:: Role of mucosal bicarbonate secretion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology.
2002 (English)In: InflammoPharmacology, ISSN 0925-4692, E-ISSN 1568-5608, Vol. 10, no 4-6, 327-332 p.Article in journal (Refereed) Published
Abstract [en]

The duodenal epithelium secretes bicarbonate at higher rates than does the stomach (or more distal small intestine) and the duodenal secretion is currently accepted as the most important defence mechanism against acid discharged from the stomach. HCO3 - entering the continuous layer of visco-elastic mucus gel on top of the epithelial surface maintains pH in its cell-facing portion at neutrality at acidities encountered in the healthy duodenum. The secretion is decreased in patients with acute and chronic duodenal ulcer disease and is inhibited by non-steroidal anti-inflammatory agents. Studies of the neurohumoral control of the duodenal alkaline secretion and of acid/base transport processes and intracellular signaling in duodenal enterocytes are currently of great research interest.

Place, publisher, year, edition, pages
2002. Vol. 10, no 4-6, 327-332 p.
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Physiology
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URN: urn:nbn:se:uu:diva-64384DOI: 10.1163/156856002321544792OAI: oai:DiVA.org:uu-64384DiVA: diva2:92295
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Flemström, GunnarSjöblom, Markus

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