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Covalent bond symmetry breaking and protein secondary structure
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
2011 (English)Article in journal (Refereed) Submitted
Abstract [en]

Both symmetry and organized breaking of symmetry have a pivotal role in our understanding of structure and pattern formation in physical systems, including the origin of mass in the Universe and the chiral structure of biological macromolecules. Here we report on a new symmetry breaking phenomenon that takes place in all biologically active proteins, thus this symmetry breaking relates to the inception of life. The unbroken symmetry determines the covalent bond geometry of a sp3 hybridized carbon atom. It dictates the tetrahedral architecture of atoms around the central carbon of an amino acid. Here we show that in a biologically active protein this symmetry becomes broken. Moreover, we show that the pattern of symmetry breaking is in a direct correspondence with the local secondary structure of the folded protein.

Place, publisher, year, edition, pages
2011.
National Category
Subatomic Physics
Research subject
Theoretical Physics
Identifiers
URN: urn:nbn:se:uu:diva-287833OAI: oai:DiVA.org:uu-287833DiVA: diva2:923514
Available from: 2016-04-26 Created: 2016-04-26 Last updated: 2016-04-26

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http://arxiv.org/abs/1109.0423

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Niemi, Antti
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