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Behavioral profiling before and after adolescent ethanol intake in rats subjected to different early-life conditions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behavior)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behavior)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behavior)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behavior)
2011 (English)Conference paper, Oral presentation only (Other academic)
Abstract [en]

Causal links between the early-life environment and later psychiatric dysfunction are difficult to study in a clinical setting. Animal studies have therefore provided valuable insights into the basis of early-life impact on disorders later in life. For instance, repeated periods of short or prolonged maternal separation differentially affect behavior and voluntary ethanol intake in adult rats. This study examined the behavioral consequences of adolescent voluntary ethanol intake in rats subjected to different rearing environments.Rat pups were subjected to daily separation from the dams for 15 min (MS15) or 360 min (MS360) during the first 21 postnatal days. At 4 weeks of age their behavior was profiled using the multivariate concentric square field™ (MCSF) test. This test has an ethological foundation and is designed to provoke exploration and behaviors associated with risk assessment, risk taking and shelter seeking. At 5 weeks of age they were given intermittent access to 20% ethanol in a two-bottle free-choice paradigm. During a deprivation period after 9 weeks of access they were again tested in the MCSF. Water drinking MS15 and MS360 rats, and animal facility reared rats were included in the profiling.A principal component analysis (PCA) indicated large individual differences in behavioral profiles within the two MS groups. A trend analysis also revealed differences between the MS15 and the MS360 in risk assessment. The median ethanol intake in the MS groups was approximately 3 g/kg/day and did not differ between groups or change over time, whereas the ethanol preference increased significantly to 30%. Thus, in line with previous findings, adolescent access to ethanol abolishes differences in intake between MS groups. Examination of the behavior before ethanol access showed that parameters correlated with initial intake differed between MS15 and MS360 rats. The effects on behavior over time also differed depending on the early environment and ethanol access. The PCA for the second MCSF test revealed that ethanol intake in the MS360 group resulted in a more homogenous behavioral profile as compared to the first trial. Correlations between ethanol intake and the profiles from the second MCSF trial were also found in different parameters depending on the rearing environment.The results show that the early environment has effects on behavior in early adolescence, as well as differential effects on adult behavior after ethanol access. Furthermore, the behavioral profiles given by the MCSF tests makes it possible to follow an individual over time in order to look at causal links between behavior and voluntary ethanol intake.

Place, publisher, year, edition, pages
2011. 469.02/EE20
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-287925OAI: oai:DiVA.org:uu-287925DiVA: diva2:923599
Conference
Neuroscience 2011, Washington DC, Nov 12-16, 2011
Note

Presentation time: Monday, Nov 14, 2011, 2:00 PM - 3:00 PM

Available from: 2016-04-26 Created: 2016-04-26 Last updated: 2017-08-29Bibliographically approved

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http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=7ea7a424-00eb-4f56-8213-18ebc838aea2&cKey=3b162d97-077a-4295-9b73-a5f2341e7c6c&mKey={8334BE29-8911-4991-8C31-32B32DD5E6C8}

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