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Cerebrospinal fluid concentration of Galectin-9 is increased in secondary progressive multiple sclerosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Univ Uppsala Hosp, Dept Neurol, SE-75185 Uppsala, Sweden.
Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden; Univ Hosp Northern Sweden, Umea, Sweden; Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 40-44 p.Article in journal (Refereed) Published
Abstract [en]

Galectin-9 is produced by activated astrocytes, induces a pro-inflammatory response in microglia and may be important to the pathogenesis of secondary progressive MS. In this study, Galectin-9 concentrations in CSF samples from healthy controls and two independent patient cohorts of MS patients were determined by ELISA. Patients from one of the cohorts underwent MRI as well. Galectin-9 concentrations in CSF were higher in SPMS patients than healthy controls and RRMS patients in both cohorts. Galectin-9 concentrations correlated with the number of lesions on T1-weighted images, but not with gadolinium enhancing lesions, IgG index or CSF cell count.

Place, publisher, year, edition, pages
2016. Vol. 292, 40-44 p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-288094DOI: 10.1016/j.jneuroim.2016.01.008ISI: 000372561600006PubMedID: 26943957OAI: oai:DiVA.org:uu-288094DiVA: diva2:923916
Available from: 2016-04-27 Created: 2016-04-27 Last updated: 2016-05-04Bibliographically approved

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