uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Cerebrospinal fluid concentration of Galectin-9 is increased in secondary progressive multiple sclerosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Univ Uppsala Hosp, Dept Neurol, SE-75185 Uppsala, Sweden.
Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden; Univ Hosp Northern Sweden, Umea, Sweden; Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 40-44 p.Article in journal (Refereed) Published
Abstract [en]

Galectin-9 is produced by activated astrocytes, induces a pro-inflammatory response in microglia and may be important to the pathogenesis of secondary progressive MS. In this study, Galectin-9 concentrations in CSF samples from healthy controls and two independent patient cohorts of MS patients were determined by ELISA. Patients from one of the cohorts underwent MRI as well. Galectin-9 concentrations in CSF were higher in SPMS patients than healthy controls and RRMS patients in both cohorts. Galectin-9 concentrations correlated with the number of lesions on T1-weighted images, but not with gadolinium enhancing lesions, IgG index or CSF cell count.

Place, publisher, year, edition, pages
2016. Vol. 292, 40-44 p.
National Category
URN: urn:nbn:se:uu:diva-288094DOI: 10.1016/j.jneuroim.2016.01.008ISI: 000372561600006PubMedID: 26943957OAI: oai:DiVA.org:uu-288094DiVA: diva2:923916
Available from: 2016-04-27 Created: 2016-04-27 Last updated: 2016-05-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Burman, Joachim
By organisation
In the same journal
Journal of Neuroimmunology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 84 hits
ReferencesLink to record
Permanent link

Direct link