YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis.
2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 52-57 p.Article in journal (Refereed) Published
YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSF YKL-40 was increased in patients with active relapsing-remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing-remitting MS patients had YKL-40 levels comparable to healthy controls.
Place, publisher, year, edition, pages
2016. Vol. 292, 52-57 p.
IdentifiersURN: urn:nbn:se:uu:diva-288096DOI: 10.1016/j.jneuroim.2016.01.013ISI: 000372561600008PubMedID: 26943959OAI: oai:DiVA.org:uu-288096DiVA: diva2:923922
FunderSwedish Research CouncilTorsten Söderbergs stiftelse