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YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Univ Uppsala Hosp, Dept Neurol, SE-75185 Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
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2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 52-57 p.Article in journal (Refereed) Published
Abstract [en]

YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSF YKL-40 was increased in patients with active relapsing-remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing-remitting MS patients had YKL-40 levels comparable to healthy controls.

Place, publisher, year, edition, pages
2016. Vol. 292, 52-57 p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-288096DOI: 10.1016/j.jneuroim.2016.01.013ISI: 000372561600008PubMedID: 26943959OAI: oai:DiVA.org:uu-288096DiVA: diva2:923922
Funder
Swedish Research CouncilTorsten Söderbergs stiftelse
Available from: 2016-04-27 Created: 2016-04-27 Last updated: 2016-05-04Bibliographically approved

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