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An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
2016 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 65, no 4, 1004-1008 p.Article in journal (Refereed) PublishedText
Abstract [en]

The lymphatic system is crucial for efficient immune surveillance and for the maintenance of a physiological pressure in the interstitial space. Even so, almost no information is available concerning the lymph drainage of the islets of Langerhans in the human pancreas. lmmunohistochemical staining allowed us to distinguish lymphatic capillaries from blood capillaries. Almost no lymphatic capillaries were found within the islets in pancreatic biopsy specimens from subjects without diabetes or from subjects with type 1 or type 2 diabetes. Lymphatic capillaries were, however, found at the islet exocrine interface, frequently located along blood capillaries and other fibrotic structures within or close to the islet capsule. Lymphatic capillaries were regularly found in the exocrine pancreas, with small lymphatic vessels located close to and around acini. Larger collecting lymphatic vessels were located in fibrotic septa between the exocrine lobules and adjacent to the ductal system of the pancreas. In summary, we report a pronounced deficiency of lymphatic capillaries in human islets, a finding with implications for immune surveillance and the regulation of interstitial fluid transport in the endocrine pancreas as well as for the pathophysiology of both type 1 and type 2 diabetes.

Place, publisher, year, edition, pages
2016. Vol. 65, no 4, 1004-1008 p.
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-286633DOI: 10.2337/db15-1285ISI: 000372859200018OAI: oai:DiVA.org:uu-286633DiVA: diva2:924280
Funder
Swedish Diabetes AssociationSwedish Child Diabetes FoundationSwedish Research Council, K2011-65X-12219-15-6, K2015-54X-12219-19-4
Available from: 2016-04-28 Created: 2016-04-21 Last updated: 2016-04-28Bibliographically approved

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Korsgren, Olle
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Department of Immunology, Genetics and Pathology
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