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Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.ORCID iD: 0000-0003-3271-0456
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 4, e0152814Article in journal (Refereed) Published
Abstract [en]

Reduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin (odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin levels may have prognostic implications.

Place, publisher, year, edition, pages
2016. Vol. 11, no 4, e0152814
Keyword [en]
Melatonin, Depression, Depressive Symptoms, Saliva, Severity, Prognosis, MADRS-S, Sheehan Disability Scale, HbA1C, Oxi-LDL, Research Domain Criteria (RDoC)
National Category
Psychiatry Neurosciences
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-291425DOI: 10.1371/journal.pone.0152814ISI: 000373592100035PubMedID: 27042858OAI: oai:DiVA.org:uu-291425DiVA: diva2:925531
Projects
Uppsala Psykiatriska Provsamling
Funder
Swedish Society of Medicine
Available from: 2016-05-02 Created: 2016-05-02 Last updated: 2017-11-30Bibliographically approved

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Sundberg, IsakRamklint, MiaStridsberg, MatsPapadopoulos, Fotios CEkselius, LisaCunningham, Janet L

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