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Associations between psychiatric symptoms and cortisol levels in Nicaraguan young school-age children
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Karolinska Inst, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, Pediat Neuropsychiat Unit, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Ctr Res & Intervent Hlth, Leon, Nicaragua.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
2016 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 240, 376-380 p.Article in journal (Refereed) Published
Abstract [en]

The regulation of the Hypothalamus-Pituitary-Adrenal axis (HPA-axis) with its end product cortisol seems to be affected in several psychiatric disorders. Although findings are not conclusive, internalizing symptoms have primarily been associated with higher diurnal cortisol levels and externalizing symptoms with lower cortisol levels. In this study on nine-year-olds in Nicaragua (n=111), we investigated associations between child psychiatric symptoms, using the Child Behavior Check List (CBCL), and saliva cortisol levels collected in the morning and afternoon, also adjusting for potential confounders. In line with previous findings, internalizing symptoms were significantly associated with higher morning, but not afternoon cortisol levels. Surprisingly, externalizing symptoms were also significantly associated with higher morning cortisol levels. Possibly, this association between externalizing symptoms and cortisol levels may be characteristic of early ages, representing a higher exposure to external stressors. The study highlights the need for prospective studies, following the development of the HPA-axis and its association with psychiatric symptoms.

Place, publisher, year, edition, pages
2016. Vol. 240, 376-380 p.
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-292594DOI: 10.1016/j.psychres.2016.04.069ISI: 000378359500060PubMedID: 27138834OAI: oai:DiVA.org:uu-292594DiVA: diva2:926117
Funder
Sida - Swedish International Development Cooperation AgencySwedish Research Council, K 2002-27 x 14290-01A
Available from: 2016-05-04 Created: 2016-05-04 Last updated: 2016-07-29Bibliographically approved

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Isaksson, JohanHögberg, UlfLindblad, Frank
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