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Ceramic cement as a potential stand-alone treatment for bone fractures: an in vitro study of ceramic-bone composites
ETH, Inst Biomech, HPP-O14,Honggerbergring 64, CH-8093 Zurich, Switzerland;ETH, Lab Surface Sci & Technol, Zurich, Switzerland.
ETH, Inst Biomech, HPP-O14,Honggerbergring 64, CH-8093 Zurich, Switzerland.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)ORCID iD: 0000-0001-6663-6536
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
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2016 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 61, 519-529 p.Article in journal (Refereed) Published
Abstract [en]

Background: A vertebral burst fracture (VBF) treated with vertebroplasty using a ceramic cement consists of four regions; native bone fragments, native ceramic cement, ceramic cement-trabecular bone (ceramic-bone) composite and ceramic-bone interface. Although the mechanical properties of native bone and native ceramic cements have been well investigated, the mechanical properties of ceramic-bone composite and ceramic-bone interface remain unknown. Therefore, the aim of this study was to determine the mechanical properties of ceramic-bone composites and ceramic-bone interfaces. Two types of ceramic cement, calcium aluminate (CAC) with (w/F) and without (wo/F) fiber reinforcement, were investigated. Methods: Ceramic-bone composite (Full, wo/F and w/F) and ceramic-bone interface (Fract, wo/F and w/F) groups were tested to determine their compressive and tensile properties. While a continuous bone cylinder was used for samples in the Full groups, each bone cylinder for the samples in the Fract groups contained a 3 mm geometrical discontinuity to mimic the fracture gaps in VBFs. Two Cement groups (wo/F and w/F) and a Bone group were included in the study as controls. Micro-CT images were used to determine the bone morphological parameters, as potential predictors of the mechanical properties of Full and Fract groups. Results: The compressive strengths of Full and Fract groups were substantially lower than native CAC, but higher than bone. The tensile strength of the Full group was equal to bone, while the tensile strength of the Fract group was equivalent to CAC. Variable relationships between the bone morphological parameters and mechanical properties of Full and Fract groups were observed. Fiber reinforcement at an injectable level had a minimal influence on the mechanical properties. Conclusions: CAC augmentation does not provide adequate stabilization of bone fragments. The interface between bone and cement represents a weak point. The effect of cement augmentation cannot be predicted by bone morphological properties.

Place, publisher, year, edition, pages
2016. Vol. 61, 519-529 p.
Keyword [en]
Compression; Tension; Ceramic cements; Fiber-reinforcement; Composite; Interface
National Category
Ceramics Applied Mechanics Medical Materials
Research subject
Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-283516DOI: 10.1016/j.jmbbm.2016.03.027ISI: 000380080400049PubMedID: 27136088OAI: oai:DiVA.org:uu-283516DiVA: diva2:926523
Available from: 2016-05-09 Created: 2016-04-13 Last updated: 2016-09-16Bibliographically approved

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Persson, CeciliaEngqvist, Håkan
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