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Unsupervised classification of single-particle X-ray diffraction snapshots by spectral clustering.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. (Molecular Biophysics)
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2011 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 19, no 17, 15929-15936 p.Article in journal (Refereed) Published
Abstract [en]

Single-particle experiments using X-ray Free Electron Lasers produce more than 10(5) snapshots per hour, consisting of an admixture of blank shots (no particle intercepted), and exposures of one or more particles. Experimental data sets also often contain unintentional contamination with different species. We present an unsupervised method able to sort experimental snapshots without recourse to templates, specific noise models, or user-directed learning. The results show 90% agreement with manual classification.

Place, publisher, year, edition, pages
2011. Vol. 19, no 17, 15929-15936 p.
National Category
Natural Sciences
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URN: urn:nbn:se:uu:diva-292911PubMedID: 21935018OAI: oai:DiVA.org:uu-292911DiVA: diva2:926958
Available from: 2016-05-10 Created: 2016-05-10 Last updated: 2016-05-10

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