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Long-term effects on brain opioid and opioid receptor like-1 receptors after short periods of maternal separation in rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2003 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 345, no 3, 195-197 p.Article in journal (Refereed) Published
Abstract [en]

Short periods of maternal separation of neonatal rats are known to induce attenuated behavioural and neuroendocrine responses to stress in adult life. The present study was carried out to evaluate whether 15 min separation from the dam during postnatal days 1-21 (MS15) can induce long-term changes in brain opioid (kappa- and delta-receptors) and opioid receptor-like 1 (ORL1) densities in male Sprague-Dawley rats. Receptor autoradiography indicated that MS15 rats had increased delta-receptor density in the basomedial amygdala compared to animal facility reared rats 2 months after MS15. No differences in brain kappa- or ORL1-receptor density were found. The results indicate that a manipulation early in life can induce persistent neurochemical changes in the delta-opioid receptor system, which suggests involvement of delta-opioid receptors in the altered emotional processing in these rats.

Place, publisher, year, edition, pages
2003. Vol. 345, no 3, 195-197 p.
Keyword [en]
maternal separation, neonatal handling, opioid receptor, ORL1 receptor, brain; stress, Sprague-Dawley rats
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-64795DOI: 10.1016/S0304-3940(03)00515-9PubMedID: 12842289OAI: oai:DiVA.org:uu-64795DiVA: diva2:92706
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Nylander, Ingrid

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