Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters
2003 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 552, no 2-3, 214-218 p.Article in journal (Refereed) Published
It is well established that adenovirus E1B-55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B-55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B-55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B-55K, suggesting that E1B-55K blocks p53 functions by interfering with the Sin3 complex.
Place, publisher, year, edition, pages
2003. Vol. 552, no 2-3, 214-218 p.
adenovirus, E1B-55K, survivin, Sin3A
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-64854DOI: 10.1016/S0014-5793(03)00927-XPubMedID: 14527689OAI: oai:DiVA.org:uu-64854DiVA: diva2:92765