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Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2003 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 552, no 2-3, 214-218 p.Article in journal (Refereed) Published
Abstract [en]

It is well established that adenovirus E1B-55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B-55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B-55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B-55K, suggesting that E1B-55K blocks p53 functions by interfering with the Sin3 complex.

Place, publisher, year, edition, pages
2003. Vol. 552, no 2-3, 214-218 p.
Keyword [en]
adenovirus, E1B-55K, survivin, Sin3A
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-64854DOI: 10.1016/S0014-5793(03)00927-XPubMedID: 14527689OAI: oai:DiVA.org:uu-64854DiVA: diva2:92765
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Punga, TanelAkusjärvi, Göran

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