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Population Genetic Nature of Copy Number Variation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology. (Mattias Jakobsson)
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology. (Mattias Jakobsson)
2012 (English)In: Genomic Strutural Variants: Methods and Protocols / [ed] Lars Feuk, Humana Press, 2012, 1, 209-223 p.Chapter in book (Other academic)
Abstract [en]

Copy number variation has recently received considerable attention, and copy number variants (CNVs) have been shown to be both common in mammalian genomes and important for understanding genetic and phenotypic variation. As empirical knowledge and detection methods are quickly advancing, evolutionary theories about CNVs are rapidly updated and often revised. Here, we review recent progress on understanding CNVs, and we discuss some key issues for future research. In essence, we discuss four major forces in population genetics, recombination, mutation, selection, and demography, in relation to CNVs.

Place, publisher, year, edition, pages
Humana Press, 2012, 1. 209-223 p.
Series
, Methods in Molecular Biology, ISSN 1064-3745 ; 838
Keyword [en]
structural variation, population genetics, mutation, recombination
National Category
Genetics
Research subject
Biology with specialization in Molecular Evolution
Identifiers
URN: urn:nbn:se:uu:diva-293554DOI: 10.1007/978-1-61779-507-7ISBN: 9781617795060OAI: oai:DiVA.org:uu-293554DiVA: diva2:927950
Funder
Carl Tryggers foundation Swedish Research Council Formas
Available from: 2016-05-13 Created: 2016-05-13 Last updated: 2016-07-27Bibliographically approved

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Publisher's full texthttp://link.springer.com/protocol/10.1007%2F978-1-61779-507-7_10

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