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Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross.
2002 (English)In: Animal Genetics, ISSN 0268-9146, E-ISSN 1365-2052, Vol. 33, no 2Article in journal (Refereed) Published
Abstract [en]

The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar x Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.

Place, publisher, year, edition, pages
2002. Vol. 33, no 2
National Category
Natural Sciences
Research subject
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-294267PubMedID: 12047230OAI: oai:DiVA.org:uu-294267DiVA: diva2:929239
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2016-05-18

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Carlborg, Örjan
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