uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Simultaneous mapping of epistatic QTL in chickens reveals clusters of QTL pairs with similar genetic effects on growth.
Roslin Institute.ORCID iD: 0000-0002-2722-5264
2004 (English)In: Genetical research, Vol. 83, no 3Article in journal (Refereed) Published
Abstract [en]

We used simultaneous mapping of interacting quantitative trait locus (QTL) pairs to study various growth traits in a chicken F2 intercross. The method was shown to increase the number of detected QTLs by 30 % compared with a traditional method detecting QTLs by their marginal genetic effects. Epistasis was shown to be an important contributor to the genetic variance of growth, with the largest impact on early growth (before 6 weeks of age). There is also evidence for a discrete set of interacting loci involved in early growth, supporting the previous findings of different genetic regulation of early and late growth in chicken. The genotype-phenotype relationship was evaluated for all interacting QTL pairs and 17 of the 21 evaluated QTL pairs could be assigned to one of four clusters in which the pairs in a cluster have very similar genetic effects on growth. The genetic effects of the pairs indicate commonly occurring dominance-by-dominance, heterosis and multiplicative interactions. The results from this study clearly illustrate the increase in power obtained by using this novel method for simultaneous detection of epistatic QTL, and also how visualization of genotype-phenotype relationships for epistatic QTL pairs provides new insights to biological mechanisms underlying complex traits.

Place, publisher, year, edition, pages
2004. Vol. 83, no 3
National Category
Natural Sciences
Research subject
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-294262PubMedID: 15462413OAI: oai:DiVA.org:uu-294262DiVA: diva2:929241
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2016-05-18

Open Access in DiVA

No full text

PubMed

Search in DiVA

By author/editor
Carlborg, Örjan
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 80 hits
ReferencesLink to record
Permanent link

Direct link