Capacitating epistasis--detection and role in the genetic architecture of complex traits.
2015 (English)In: Methods in Molecular Biology, ISSN 1064-3745, E-ISSN 1940-6029, Vol. 1253Article in journal (Refereed) Published
Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.
Place, publisher, year, edition, pages
2015. Vol. 1253
Research subject Bioinformatics
IdentifiersURN: urn:nbn:se:uu:diva-294200DOI: 10.1007/978-1-4939-2155-3_10PubMedID: 25403533OAI: oai:DiVA.org:uu-294200DiVA: diva2:929251