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Capacitating epistasis--detection and role in the genetic architecture of complex traits.
2015 (English)In: Methods in Molecular Biology, ISSN 1064-3745, E-ISSN 1940-6029, Vol. 1253Article in journal (Refereed) Published
Abstract [en]

Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.

Place, publisher, year, edition, pages
2015. Vol. 1253
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Natural Sciences
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URN: urn:nbn:se:uu:diva-294200DOI: 10.1007/978-1-4939-2155-3_10PubMedID: 25403533OAI: oai:DiVA.org:uu-294200DiVA: diva2:929251
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2016-05-18

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Carlborg, Örjan
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