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Estimation and interpretation of genetic effects with epistasis using the NOIA model.
2012 (English)In: Methods in Molecular Biology, ISSN 1064-3745, E-ISSN 1940-6029, Vol. 871Article in journal (Refereed) Published
Abstract [en]

We introduce this communication with a brief outline of the historical landmarks in genetic modeling, especially concerning epistasis. Then, we present methods for the use of genetic modeling in QTL analyses. In particular, we summarize the essential expressions of the natural and orthogonal interactions (NOIA) model of genetic effects. Our motivation for reviewing that theory here is twofold. First, this review presents a digest of the expressions for the application of the NOIA model, which are often mixed with intermediate and additional formulae in the original articles. Second, we make the required theory handy for the reader to relate the genetic concepts to the particular mathematical expressions underlying them. We illustrate those relations by providing graphical interpretations and a diagram summarizing the key features for applying genetic modeling with epistasis in comprehensive QTL analyses. Finally, we briefly review some examples of the application of NOIA to real data and the way it improves the interpretability of the results.

Place, publisher, year, edition, pages
2012. Vol. 871
National Category
Natural Sciences
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:uu:diva-294222DOI: 10.1007/978-1-61779-785-9_10PubMedID: 22565838OAI: oai:DiVA.org:uu-294222DiVA: diva2:929271
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2016-05-18

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Carlborg, Örjan
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