Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX)Enzyme Activities
2003 (English)In: Chemical and pharmaceutical bulletin, ISSN 0009-2363, E-ISSN 1347-5223, Vol. 51, no 12, 1439-1440 p.Article in journal (Refereed) Published
Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.
Place, publisher, year, edition, pages
2003. Vol. 51, no 12, 1439-1440 p.
Hypericum laricifolium, Guttiferae, caffeate ester, flavonol, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2)
IdentifiersURN: urn:nbn:se:uu:diva-65037DOI: 10.1248/cpb.51.1439ISI: 000187001900020PubMedID: 14646327OAI: oai:DiVA.org:uu-65037DiVA: diva2:92948