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Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX)Enzyme Activities
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
2003 (English)In: Chemical and pharmaceutical bulletin, ISSN 0009-2363, E-ISSN 1347-5223, Vol. 51, no 12, 1439-1440 p.Article in journal (Refereed) Published
Abstract [en]

Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.

Place, publisher, year, edition, pages
2003. Vol. 51, no 12, 1439-1440 p.
Keyword [en]
Hypericum laricifolium, Guttiferae, caffeate ester, flavonol, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2)
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-65037DOI: 10.1248/cpb.51.1439ISI: 000187001900020PubMedID: 14646327OAI: oai:DiVA.org:uu-65037DiVA: diva2:92948
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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