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Gene expression analysis reveals that Delta/Notch signalling is not involved in onychophoran segmentation
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
2016 (English)In: Development, Genes and Evolution, ISSN 0949-944X, E-ISSN 1432-041X, Vol. 226, no 2, 69-77 p.Article in journal (Refereed) Published
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Abstract [en]

Delta/Notch (Dl/N) signalling is involved in the gene regulatory network underlying the segmentation process in vertebrates and possibly also in annelids and arthropods, leading to the hypothesis that segmentation may have evolved in the last common ancestor of bilaterian animals. Because of seemingly contradicting results within the well-studied arthropods, however, the role and origin of Dl/N signalling in segmentation generally is still unclear. In this study, we investigate core components of Dl/N signalling by means of gene expression analysis in the onychophoran Euperipatoides kanangrensis, a close relative to the arthropods. We find that neither Delta or Notch nor any other investigated components of its signalling pathway are likely to be involved in segment addition in onychophorans. We instead suggest that Dl/N signalling may be involved in posterior elongation, another conserved function of these genes. We suggest further that the posterior elongation network, rather than classic Dl/N signalling, may be in the control of the highly conserved segment polarity gene network and the lower-level pair-rule gene network in onychophorans. Consequently, we believe that the pair-rule gene network and its interaction with Dl/N signalling may have evolved within the arthropod lineage and that Dl/N signalling has thus likely been recruited independently for segment addition in different phyla.

Place, publisher, year, edition, pages
2016. Vol. 226, no 2, 69-77 p.
Keyword [en]
Onychophora, Segmentation, Delta, Notch, Posterior elongation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-294327DOI: 10.1007/s00427-016-0529-4ISI: 000373156300003PubMedID: 26935716OAI: oai:DiVA.org:uu-294327DiVA: diva2:929489
Funder
Swedish Research Council
Available from: 2016-05-18 Created: 2016-05-18 Last updated: 2017-11-30Bibliographically approved

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Janssen, RalfBudd, Graham E.

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