Rapid and straightforward transesterification of sulfonyl carbamates
2016 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 57, no 13, 1476-1478 p.Article in journal (Refereed) PublishedText
A fast and convenient method for the alkoxy exchange of sulfonyl carbamates by simply heating in a chosen alkyl alcohol is described. No catalysts or additives are required. Microwave heating at 100-120 degrees C for 20-60 min resulted in good to excellent yields (53-93%) of alkyl (arylsulfonyl)carbamates where the alkyl part originates from the alcohol solvent. The developed protocol was applied to the synthesis of an angiotensin II type 2 receptor (AT2R) ligand.
Place, publisher, year, edition, pages
2016. Vol. 57, no 13, 1476-1478 p.
Sulfonyl carbamates, O-alkyl exchange, Transesterification, Carboxylic acid bioisosteres, AT2R ligand
IdentifiersURN: urn:nbn:se:uu:diva-294300DOI: 10.1016/j.tetlet.2016.02.071ISI: 000372690800018OAI: oai:DiVA.org:uu-294300DiVA: diva2:929566
FunderEU, FP7, Seventh Framework Programme, REGPOT-CT-2013-316149-InnovaBalt