uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?
Univ Roma La Sapienza, Ist Pasteur, Fdn Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Rome, Italy.;Univ Roma La Sapienza, Ist Biol & Patol Mol, CNR, Dipartimento Sci Biochim A Rossi Fanelli, Piazzale Aldo Moro 5, I-00185 Rome, Italy.;Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England..
Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 36, 18-24 p.Article in journal (Refereed) PublishedText
Abstract [en]

Protein or protein regions that are not forming well-defined structures in their free states under native-like conditions are called intrinsically disordered proteins. Such proteins are very common in protein-protein interactions, where their disorder apparently gives several advantages including optimal binding properties. To fully appreciate why protein disorder is advantageous for protein-protein interactions we need to understand the mechanism(s) of interaction. However, elucidating mechanisms in protein-protein interactions is usually very challenging. Here we discuss how kinetics in combination with protein engineering and structural information can be used to depict details of protein-protein interactions involving intrinsically disordered proteins.

Place, publisher, year, edition, pages
2016. Vol. 36, 18-24 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-294591DOI: 10.1016/j.sbi.2015.11.012ISI: 000372681200005PubMedID: 26720267OAI: oai:DiVA.org:uu-294591DiVA: diva2:931005
Funder
Swedish Research Council, 2012-5096, 2014-4299
Available from: 2016-05-26 Created: 2016-05-25 Last updated: 2016-05-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jemth, Per
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Current opinion in structural biology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 199 hits
ReferencesLink to record
Permanent link

Direct link