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Signals and Receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Salk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA..
Salk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA..
Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA..
2016 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, E-ISSN 1943-0264, Vol. 8, no 4, a005900Article in journal (Refereed) PublishedText
Abstract [en]

Communication between cells in a multicellular organism occurs by the production of ligands (proteins, peptides, fatty acids, steroids, gases, and other low-molecular-weight compounds) that are either secreted by cells or presented on their surface, and act on receptors on, or in, other target cells. Such signals control cell growth, migration, survival, and differentiation. Signaling receptors can be single-span plasma membrane receptors associated with tyrosine or serine/threonine kinase activities, proteins with seven transmembrane domains, or intracellular receptors. Ligand-activated receptors convey signals into the cell by activating signaling pathways that ultimately affect cytosolic machineries or nuclear transcriptional programs or by directly translocating to the nucleus to regulate transcription.

Place, publisher, year, edition, pages
2016. Vol. 8, no 4, a005900
National Category
Cell Biology
URN: urn:nbn:se:uu:diva-294684DOI: 10.1101/cshperspect.a005900ISI: 000373486900006OAI: oai:DiVA.org:uu-294684DiVA: diva2:932243
Available from: 2016-06-01 Created: 2016-05-26 Last updated: 2016-06-01Bibliographically approved

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Heldin, Carl-Henrik
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Ludwig Institute for Cancer ResearchScience for Life Laboratory, SciLifeLab
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