Signals and Receptors
2016 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, E-ISSN 1943-0264, Vol. 8, no 4, a005900Article in journal (Refereed) PublishedText
Communication between cells in a multicellular organism occurs by the production of ligands (proteins, peptides, fatty acids, steroids, gases, and other low-molecular-weight compounds) that are either secreted by cells or presented on their surface, and act on receptors on, or in, other target cells. Such signals control cell growth, migration, survival, and differentiation. Signaling receptors can be single-span plasma membrane receptors associated with tyrosine or serine/threonine kinase activities, proteins with seven transmembrane domains, or intracellular receptors. Ligand-activated receptors convey signals into the cell by activating signaling pathways that ultimately affect cytosolic machineries or nuclear transcriptional programs or by directly translocating to the nucleus to regulate transcription.
Place, publisher, year, edition, pages
2016. Vol. 8, no 4, a005900
IdentifiersURN: urn:nbn:se:uu:diva-294684DOI: 10.1101/cshperspect.a005900ISI: 000373486900006OAI: oai:DiVA.org:uu-294684DiVA: diva2:932243