CYP2D6 genotypes and depressive symptoms during late pregnancy and postpartum
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences2004 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 58, no 1, 61-4 p.Article in journal (Refereed) Published
The aim of this exploratory was to investigate the theory of a relation between cytochrome P450 2D6 (CYP2D6) genotype and depressive symptoms in late pregnancy and/or postpartum. We studied 145 women with depressive symptoms. CYP2D6 genotype was analysed in leukocyte DNA by polymerase chain reaction (PCR). There were no significant differences in CYP2D6 genotypes between the groups of women being depressed during and/or after pregnancy. The frequencies of CYP2D6 genotypes did not differ from other European studies. This study cannot confirm that depressive symptoms in late pregnancy and postpartum are connected with CYP2D6 genotype. It is, however, noteworthy that the frequency of ultrarapid metabolizers was higher than in a general Caucasian population. This warrants further exploration in a greater study sample, but should also be investigated in a general population with major depression.
Place, publisher, year, edition, pages
2004. Vol. 58, no 1, 61-4 p.
CYP2D6, Depression, Pregnancy, Postpartum
Medical Genetics Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:uu:diva-65334DOI: 10.1080/08039480310000815PubMedID: 14985156 OAI: oai:DiVA.org:uu-65334DiVA: diva2:93245