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Padlock and proximity probes for in situ and array-based analyses: tools for the post genomic era
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2003 (English)In: Comparative and functional genomics, ISSN 1531-6912, E-ISSN 1532-6268, Vol. 4, no 5, 525-30 p.Article in journal (Refereed) Published
Abstract [en]

Highly specific high-throughput assays will be required to take full advantage of the accumulating information about the macromolecular composition of cells and tissues, in order to characterize biological systems in health and disease. We discuss the general problem of detection specificity and present the approach our group has taken, involving the reformatting of analogue biological information to digital reporter segments of genetic information via a series of DNA ligation assays. The assays enable extensive, coordinated analyses of the numbers and locations of genes, transcripts and protein.

Place, publisher, year, edition, pages
2003. Vol. 4, no 5, 525-30 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-65439DOI: 10.1002/cfg.326PubMedID: 18629012OAI: oai:DiVA.org:uu-65439DiVA: diva2:93350
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Landegren, UlfNilsson, MatsSöderberg, OlaEricsson, OlleStenberg, Johan

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