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Molecular tools for a molecular medicine: analyzing genes, transcripts and proteins using padlock and proximity probes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2004 (English)In: Journal of Molecular Recognition, ISSN 0952-3499, E-ISSN 1099-1352, Vol. 17, no 3, 194-7 p.Article in journal (Refereed) Published
Abstract [en]

Procedures and reagents are needed to specifically detect all the macromolecules that are being identified in the course of genome projects. We discuss how this challenge may be met using a set of ligation-based reagents termed padlock probes and proximity ligation probes. These probes include elements with affinity for specific nucleic acid and protein molecules, respectively, along with unique identifier DNA sequence elements that encode the identity of the recognized target molecules. The information content of DNA strands that form in the detection reactions are recorded after amplification, allowing the recognized target molecules to be identified. The procedures permit highly specific solution-phase or localized analyses of large sets of target molecules as required in future molecular analyses.

Place, publisher, year, edition, pages
2004. Vol. 17, no 3, 194-7 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-65440DOI: 10.1002/jmr.664PubMedID: 15137029OAI: oai:DiVA.org:uu-65440DiVA: diva2:93351
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-30Bibliographically approved

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Landegren, UlfNilsson, MatsSöderberg, OlaEricsson, OlleStenberg, Johan

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