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Corticolimbic anatomical characteristics predetermine risk for chronic pain
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2016 (English)In: Brain, ISSN 0006-8950, E-ISSN 1460-2156, Vol. 139, p. 1958-1970Article in journal (Refereed) Published
Abstract [en]

Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.

Place, publisher, year, edition, pages
2016. Vol. 139, p. 1958-1970
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-295756DOI: 10.1093/brain/aww100ISI: 000379763000017PubMedID: 27190016OAI: oai:DiVA.org:uu-295756DiVA: diva2:934649
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, FAS: 2011-0627
Available from: 2016-06-09 Created: 2016-06-09 Last updated: 2017-11-30Bibliographically approved

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Comasco, Erika

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