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Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2003 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 530, 653-659 p.Article in journal (Refereed) Published
Abstract [en]

We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats. RESULTS: In normoglycemic rats, CM injection induced a transient decrease followed by an increase in renal cortical blood flow (CBF), whereas CBF increased directly in the diabetic animals. Renal outer medullary blood flow (OMBF) increased in controls, while it decreased in the diabetic animals following CM injection. In control rats a marked initial decrease in OM pO2 following injection of CM was observed. In animals diabetic for 4 weeks only a slight decrease was seen, whereas in 9-week diabetic animals a persistent increase was recorded. CONCLUSIONS: An altered oxygen tension and hemodynamic response to CM was found in diabetic rats. If these disturbances may contribute to the development of renal dysfunction by CM in the diabetic rat kidney remains to be elucidated.

Place, publisher, year, edition, pages
2003. Vol. 530, 653-659 p.
Keyword [en]
Animals, Contrast Media/*pharmacology, Diabetes Mellitus; Experimental/*metabolism/physiopathology, Hemodynamics/*drug effects, Iohexol/*analogs & derivatives/*pharmacology, Kidney/*metabolism/physiology, Male, Rats, Rats; Inbred WF, Streptozocin
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-65668PubMedID: 14562763OAI: oai:DiVA.org:uu-65668DiVA: diva2:93579
Available from: 2007-11-07 Created: 2007-11-07 Last updated: 2017-11-28Bibliographically approved

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Palm, FredrikCarlsson, Per-OlaFasching, AngelicaHansell, PeterLiss, Per

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