Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney
2003 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 530, 653-659 p.Article in journal (Refereed) Published
We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats. RESULTS: In normoglycemic rats, CM injection induced a transient decrease followed by an increase in renal cortical blood flow (CBF), whereas CBF increased directly in the diabetic animals. Renal outer medullary blood flow (OMBF) increased in controls, while it decreased in the diabetic animals following CM injection. In control rats a marked initial decrease in OM pO2 following injection of CM was observed. In animals diabetic for 4 weeks only a slight decrease was seen, whereas in 9-week diabetic animals a persistent increase was recorded. CONCLUSIONS: An altered oxygen tension and hemodynamic response to CM was found in diabetic rats. If these disturbances may contribute to the development of renal dysfunction by CM in the diabetic rat kidney remains to be elucidated.
Place, publisher, year, edition, pages
2003. Vol. 530, 653-659 p.
Animals, Contrast Media/*pharmacology, Diabetes Mellitus; Experimental/*metabolism/physiopathology, Hemodynamics/*drug effects, Iohexol/*analogs & derivatives/*pharmacology, Kidney/*metabolism/physiology, Male, Rats, Rats; Inbred WF, Streptozocin
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-65668PubMedID: 14562763OAI: oai:DiVA.org:uu-65668DiVA: diva2:93579