IgA antibodies to gliadin and coeliac disease in psoriatic arthritis
2002 (English)In: Rheumatology (Oxford, England), ISSN 1462-0324, Vol. 41, no 1, 31-37 p.Article in journal (Refereed) Published
OBJECTIVES: To find out whether patients with psoriatic arthritis (PsoA) have an increased prevalence of antibodies to gliadin (AGA) and of coeliac disease. METHODS: One hundred and fourteen PsoA patients with skin disease of 20+/-13 yr and joint disease of 11+/-10 yr duration answered a questionnaire concerning their medical history and underwent clinical examination, including radiology. Serum IgA AGA and IgG AGA, IgA antibodies to endomysium and immunoglobulins, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration were determined. RESULTS: Five of the 114 patients (4.4%) had coeliac disease. After exclusion of these five patients, the mean IgA AGA concentration was significantly higher (P=0.0005) than that in a reference group. None of the patients had IgA antibodies to endomysium. The mean serum IgA concentration was significantly increased and IgM decreased. Patients with a high concentration of IgA AGA had significantly higher ESR and CRP and a longer duration of morning stiffness than those with a low AGA concentration. CONCLUSIONS: Patients with PsoA have an increased prevalence of raised serum IgA AGA and of coeliac disease. Patients with raised IgA AGA seem to have more pronounced inflammation than those with a low IgA AGA concentration.
Place, publisher, year, edition, pages
2002. Vol. 41, no 1, 31-37 p.
Crohn's disease, Ulcerative colitis, Endomysium antibodies, Autoimmune thyroid disease, Concomitant diseases
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-65696PubMedID: 11792877OAI: oai:DiVA.org:uu-65696DiVA: diva2:93607