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The Genetic Basis of Systemic Lupus Erythematosus – knowledge of today and thoughts for tomorrow
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
2004 (English)In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 13, no Spec no 1, R143 p.R143-8 p.Article in journal (Other academic) Published
Abstract [en]

Systemic lupus erythematosus (SLE) is a chronic rheumatic disease with an autoimmune etiology. Nuclear components of the cells are the main targets of the autoimmune reaction, affecting virtually any organ in the body. SLE is also called a prototype disease due to a substantial overlap in its clinical symptoms with other autoimmune diseases. Therefore the understanding of the mechanisms underlying SLE may contribute to advances in studies and development of new treatments for several autoimmune diseases. SLE is a complex disease with both genetic factors (mutations or susceptibility alleles) and environmental factors (infections, drugs, stress, exposures, etc.) contributing to its development. In this article we will give an overview of the latest findings in genetics of SLE, concentrating on the two most interesting and promising pathways: the PD-1 and the interferon pathways.

Place, publisher, year, edition, pages
2004. Vol. 13, no Spec no 1, R143 p.R143-8 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-65736DOI: 10.1093/hmg/ddh076PubMedID: 14764622OAI: oai:DiVA.org:uu-65736DiVA: diva2:93647
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-28Bibliographically approved

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