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Is there any association between myocardial infarction, gastro-oesophagealreflux disease and acid-suppressing drugs?
The Cardiovascular Institute, Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg.
2003 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 18, no 10, 973-978 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND

A link between gastro-oesophageal reflux disease and coronary heart disease has been suggested.

AIM

To estimate the incidence of myocardial infarction in patients with newly diagnosed gastro-oesophageal reflux disease in comparison with that in the general population.

METHODS

A population-based cohort study was performed in the UK. Patients aged 18-79 years with a first diagnosis of gastro-oesophageal reflux disease (n = 7084) were identified and a group of 10,000 patients free of gastro-oesophageal reflux disease were sampled. A nested case-control analysis was performed to assess the risk factors for myocardial infarction.

RESULTS

The incidence of myocardial infarction in the general population was 4.0 per 1,000 person-years [95% confidence interval (CI), 3.2-4.9] and 5.1 per 1,000 person-years (95% CI, 4.1-6.4) in patients with gastro-oesophageal reflux disease. The relative risk of myocardial infarction in patients with gastro-oesophageal reflux disease was 1.4 (95% CI, 1.0-1.9). The increased risk of myocardial infarction was limited to the immediate days after the diagnosis of gastro-oesophageal reflux disease. Previous chest pain was an important predictor of myocardial infarction in patients free of gastro-oesophageal reflux disease. No association was found between the use of acid-suppressing drugs and the risk of myocardial infarction.

CONCLUSION

Our results suggest that gastro-oesophageal reflux disease is not an independent predictor of myocardial infarction. Rather, the increased risk of myocardial infarction in patients with gastro-oesophageal reflux disease in the immediate days after diagnosis indicates that prodromal ischaemic symptoms were misinterpreted as reflux symptoms.

Place, publisher, year, edition, pages
2003. Vol. 18, no 10, 973-978 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-65871DOI: 10.1046/j.1365-2036.2003.01798.xPubMedID: 14616162OAI: oai:DiVA.org:uu-65871DiVA: diva2:93782
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-28Bibliographically approved

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Wallander, Mari-Ann

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