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Is there any association between myocardial infarction, gastro-oesophagealreflux disease and acid-suppressing drugs?
The Cardiovascular Institute, Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg.
2003 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 18, no 10, p. 973-978Article in journal (Refereed) Published
Abstract [en]

BACKGROUND

A link between gastro-oesophageal reflux disease and coronary heart disease has been suggested.

AIM

To estimate the incidence of myocardial infarction in patients with newly diagnosed gastro-oesophageal reflux disease in comparison with that in the general population.

METHODS

A population-based cohort study was performed in the UK. Patients aged 18-79 years with a first diagnosis of gastro-oesophageal reflux disease (n = 7084) were identified and a group of 10,000 patients free of gastro-oesophageal reflux disease were sampled. A nested case-control analysis was performed to assess the risk factors for myocardial infarction.

RESULTS

The incidence of myocardial infarction in the general population was 4.0 per 1,000 person-years [95% confidence interval (CI), 3.2-4.9] and 5.1 per 1,000 person-years (95% CI, 4.1-6.4) in patients with gastro-oesophageal reflux disease. The relative risk of myocardial infarction in patients with gastro-oesophageal reflux disease was 1.4 (95% CI, 1.0-1.9). The increased risk of myocardial infarction was limited to the immediate days after the diagnosis of gastro-oesophageal reflux disease. Previous chest pain was an important predictor of myocardial infarction in patients free of gastro-oesophageal reflux disease. No association was found between the use of acid-suppressing drugs and the risk of myocardial infarction.

CONCLUSION

Our results suggest that gastro-oesophageal reflux disease is not an independent predictor of myocardial infarction. Rather, the increased risk of myocardial infarction in patients with gastro-oesophageal reflux disease in the immediate days after diagnosis indicates that prodromal ischaemic symptoms were misinterpreted as reflux symptoms.

Place, publisher, year, edition, pages
2003. Vol. 18, no 10, p. 973-978
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-65871DOI: 10.1046/j.1365-2036.2003.01798.xPubMedID: 14616162OAI: oai:DiVA.org:uu-65871DiVA, id: diva2:93782
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-11-28Bibliographically approved

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Wallander, Mari-Ann

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