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Can guanfacine enhance memory in rats that have voluntarily been drinking alcohol for seven months?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Karolinska Institutet. (Ingrid Nylander)
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 300 HE creditsStudent thesis
Abstract [en]

Aim: To determine whether guanfacine can enhance cognition, more specific long-term memory in rats that voluntarily had been drinking high amount of ethanol for seven months.

Background: The prevalence of alcohol use disorder (AUD) is increasing at an alarming rate. One problems associated with the AUD is decreased cognitive function. Recent studies indicate that guanfacine, an alpha-2-adrenoceptor agonist, reduces voluntary alcohol consumption in rats. Guanfacine has also been shown to improve impulse control and is FDAapproved for the treatment of ADHD.

Methods: Rats were exposed to alcohol using the “intermittent-access- 20% ethanol- twobottle-choice-drink-model". Two bottles were always available, one of which contained ethanol three days a week. Water was always freely available. After seven months, the rats were subjected to the Novel Object Recognition test (NOR), which evaluates rodents memory by discriminating a novel object from a familiar one. The NOR test consists of three sessions: habituation, training and test session. Half of the rats were injected with guanfacine and half with saline before subjected to the training session. Discrimination ratio, defined as the difference in exploration time for the novel objects divided by total exploration time, was determined and compared between the two treatment groups.

Results: The data for discrimination ratio for the novel object was not significant different between the guanfacine and vehicle treated animals.

Conclusion: The present findings indicate that guanfacine does not affect the memory function examined in the NOR test in rats that have been drinking alcohol for a long period of time.

Place, publisher, year, edition, pages
2016. , 27 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-296473OAI: oai:DiVA.org:uu-296473DiVA: diva2:938512
External cooperation
Pia Steensland
Subject / course
Pharmaceutical Pharmacology
Educational program
Master of Science Programme in Pharmacy
2013-01-16, C8:321, Husargatan 3, 751 23 Uppsala, Uppsala, 09:15 (Norwegian)
Available from: 2016-06-20 Created: 2016-06-17 Last updated: 2016-06-20Bibliographically approved

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