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Strong Maternal Effects on Gene Expression in Arabidopsis lyrata Hybrids
Lund Univ, Mol Ecol & Evolut Lab, Dept Biol, Lund, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Linkoping Univ, IFM Biol, Linkoping, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.ORCID iD: 0000-0001-9573-2463
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2016 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 33, no 4, 984-994 p.Article in journal (Refereed) PublishedText
Abstract [en]

Hybridization between populations or species can have pronounced fitness consequences. Yet little is known about how hybridization affects gene regulation. Three main models have been put forward to explain gene expression patterns in hybrids: additive, dominance, or parental effects. Here, we use high throughput RNA-sequencing to examine the extent to which hybrid gene expression follows predictions by each of the three models. We performed a reciprocal crossing experiment between two differentiated populations of the perennial herb Arabidopsis lyrata and sequenced RNA in rosette leaves of 12-week-old plants grown in greenhouse conditions. The two parental populations had highly differentiated gene expression patterns. In hybrids, a majority of genes showed intermediate expression relative to that of their parental populations (i.e., additive effects), but expression was frequently more similar to the maternal than to their paternal population (i.e., maternal effects). Allele-specific expression analyses showed that in the vast majority of cases, genes with pronounced maternal effect expressed both the maternal and the paternal allele. Maternal effects on hybrid gene expression have rarely been documented previously and our study suggests it could be more common than previously assumed. Whether the maternal effect on gene expression persists to later life-stages, and whether the variation in gene expression is manifested in other aspects of the phenotype, remain to be elucidated. Our findings are relevant for understanding the consequences of outbreeding and hybridization and open up several questions for future studies.

Place, publisher, year, edition, pages
2016. Vol. 33, no 4, 984-994 p.
Keyword [en]
hybridization, gene expression, maternal effect, additive effect, Arabidopsis lyrata, RNA-Seq
National Category
Biochemistry and Molecular Biology Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-296868DOI: 10.1093/molbev/msv342ISI: 000374226700011PubMedID: 26685177OAI: oai:DiVA.org:uu-296868DiVA: diva2:940148
Funder
Swedish Research CouncilThe Crafoord Foundation
Available from: 2016-06-20 Created: 2016-06-20 Last updated: 2016-06-20Bibliographically approved

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Sletvold, NinaÅgren, Jon
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