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Self-rated health and interleukin-6: Longitudinal relationships in older adults
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, National Center for Disaster Psychiatry. Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden..
Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.;Karolinska Inst, Osher Ctr Integrat Med, Stockholm, Sweden..
Univ Kentucky, Dept Psychol, 125 Kastle Hall, Lexington, KY 40506 USA..
Univ Kentucky, Dept Psychol, 125 Kastle Hall, Lexington, KY 40506 USA..
2016 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 54, 226-232 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Both self-rated health (SRH) and inflammation are implicated in chronic diseases and premature mortality. Better SRH is associated with lower proinflammatory cytokines, but there is little evidence about whether this relationship is more stable or dynamic. Objective: To study the between- and within-person associations between SRH and IL-6. Methods: Older adults (N = 131; M-age = 75 years) rated their health and provided blood samples for analysis of IL-6 at separate occasions every 6 months over a period up to 5 years. Age, sex, BMI, neuroticism, and statin use were examined as covariates in multilevel models. Results: In bivariate models, better SRH, lower BMI, younger age, and female sex correlated with lower IL-6. In multilevel models, stable SRH (between-person differences; p < .001) but not dynamic SRH (within-person changes; p = .93) correlated with IL-6. The stable relationship persisted with demographic and health covariates in the model. Conclusions: Better stable SRH but not dynamic SRH was robustly associated with lower IL-6 among older adults, lending support to previous cross-sectional findings on the relation between inflammatory markers and SRH. The findings suggest that trait-like mechanisms, rather than changes over a time scale of 6-month waves, govern this association. To further investigate the mechanisms behind the SRH-IL-6 association, studies with different measurement frequencies, higher within-person variability, and experimental approaches are warranted.

Place, publisher, year, edition, pages
2016. Vol. 54, 226-232 p.
Keyword [en]
Self-rated health, Interleukin-6, Cytokines, Longitudinal study
National Category
Neurology Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-296847DOI: 10.1016/j.bbi.2016.02.008ISI: 000374207200022PubMedID: 26872420OAI: oai:DiVA.org:uu-296847DiVA: diva2:940254
Available from: 2016-06-20 Created: 2016-06-20 Last updated: 2016-06-20Bibliographically approved

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Arnberg, Filip K.
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Psychiatry, University HospitalNational Center for Disaster Psychiatry
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