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Effects of anesthesia on the respiratory system
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Astmanland Hosp Vasteras, Dept Anaesthesia & Intens Care, SE-72189 Vasteras, Sweden..
2015 (English)In: Best practice & research Clinical anaesthesiology, ISSN 1521-6896, E-ISSN 1532-169X, Vol. 29, no 3, 273-284 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Most anesthetics cause a loss of muscle tone that is accompanied by a fall in the resting lung volume. The lowered lung volume promotes cyclic (tidal) or continuous airway closure. High inspired oxygen fractions cause rapid absorption of gas behind closed airways, resulting in atelectasis. This chapter deals with these mechanisms in more detail, and it addresses possible measures to keep the lung open with the use of recruitment maneuvers, continuous and/or end-expiratory positive pressure, as well as the interaction with different oxygen concentrations. The effects on ventilation/perfusion matching and pulmonary gas exchange are also discussed.

Place, publisher, year, edition, pages
2015. Vol. 29, no 3, 273-284 p.
Keyword [en]
anesthesia, functional residual capacity, oxygen fraction, atelectasis, positive pressure ventilation
National Category
URN: urn:nbn:se:uu:diva-296911DOI: 10.1016/j.bpa.2015.08.008ISI: 000371591500002PubMedID: 26643094OAI: oai:DiVA.org:uu-296911DiVA: diva2:940754
Available from: 2016-06-21 Created: 2016-06-20 Last updated: 2016-06-21Bibliographically approved

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