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Investigating DNA Radiation Damage Using X-Ray Absorption Spectroscopy
Paul Scherrer Inst, Villigen, Switzerland.;Polish Acad Sci, Inst Nucl Phys, Krakow, Poland..
Paul Scherrer Inst, Villigen, Switzerland.;Jan Kochanowski Univ Humanities & Sci, Inst Phys, Kielce, Poland..
Paul Scherrer Inst, Villigen, Switzerland..
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2016 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 110, no 6, 1304-1311 p.Article in journal (Refereed) PublishedText
Abstract [en]

The biological influence of radiation on living matter has been studied for years; however, several questions about the detailed mechanism of radiation damage formation remain largely unanswered. Among all biomolecules exposed to radiation, DNA plays an important role because any damage to its molecular structure can affect the whole cell and may lead to chromosomal rearrangements resulting in genomic instability or cell death. To identify and characterize damage induced in the DNA sugar-phosphate backbone, in this work we performed x-ray absorption spectroscopy at the P K-edge on DNA irradiated with either UVA light or protons. By combining the experimental results with theoretical calculations, we were able to establish the types and relative ratio of lesions produced by both UVA and protons around the phosphorus atoms in DNA.

Place, publisher, year, edition, pages
2016. Vol. 110, no 6, 1304-1311 p.
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Biophysics
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URN: urn:nbn:se:uu:diva-295569DOI: 10.1016/j.bpj.2016.01.031ISI: 000373487200012PubMedID: 27028640OAI: oai:DiVA.org:uu-295569DiVA: diva2:941268
Available from: 2016-06-22 Created: 2016-06-08 Last updated: 2016-06-22Bibliographically approved

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