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Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster
UCL, Res Dept Genet Evolut & Environm, London, England.;Univ Queensland, Sch Biol Sci, St Lucia, Qld, Australia..
UCL, Res Dept Genet Evolut & Environm, London, England..
UCL, Res Dept Genet Evolut & Environm, London, England..
UCL, Res Dept Genet Evolut & Environm, London, England..
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2016 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 70, no 4, 781-795 p.Article in journal (Refereed) PublishedText
Abstract [en]

Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution toward optimal sex-specific phenotypes. Despite its importance for sex-specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the LHM population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for around 200 generations. Although heritabilities of male and female fitness were similar, the intersexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at nonrandom loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution toward SA resolution has occurred in one of the populations and open avenues toward studying the genetics of SA and its resolution.

Place, publisher, year, edition, pages
2016. Vol. 70, no 4, 781-795 p.
Keyword [en]
Adaptation, evolutionary genomics, fitness, population genetics, quantitative genetics, sexual conflict
National Category
Developmental Biology
URN: urn:nbn:se:uu:diva-297380DOI: 10.1111/evo.12892ISI: 000374341100004PubMedID: 27077679OAI: oai:DiVA.org:uu-297380DiVA: diva2:941644
Swedish Research Council, 2004-2572Swedish Research Council, 2006-2848Swedish Research Council, 2008-5533EU, European Research Council, 280632
Available from: 2016-06-22 Created: 2016-06-22 Last updated: 2016-06-22Bibliographically approved

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