uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Vital capacity and COPD: the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Occupat & Environm Med,Dept Mol & Clin Med, Box 414, S-40530 Gothenburg, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Occupat & Environm Med,Dept Mol & Clin Med, Box 414, S-40530 Gothenburg, Sweden..
Umea Univ, Div Med Resp Med, Dept Publ Hlth & Clin Med, Umea, Sweden..
Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Radiol, S-40530 Gothenburg, Sweden..
Show others and affiliations
2016 (English)In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 11, 927-933 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Spirometric diagnosis of chronic obstructive pulmonary disease (COPD) is based on the ratio of forced expiratory volume in 1 second (FEV1)/vital capacity (VC), either as a fixed value <0.7 or below the lower limit of normal (LLN). Forced vital capacity (FVC) is a proxy for VC. The first aim was to compare the use of FVC and VC, assessed as the highest value of FVC or slow vital capacity (SVC), when assessing the FEV1/VC ratio in a general population setting. The second aim was to evaluate the characteristics of subjects with COPD who obtained a higher SVC than FVC. Methods: Subjects (n=1,050) aged 50-64 years were investigated with FEV1, FVC, and SVC after bronchodilation. Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPDFVC was defined as FEV1/FVC <0.7, GOLDCOPD(VC) as FEV1/VC <0.7 using the maximum value of FVC or SVC, LLNCOPDFVC as FEV1/FVC below the LLN, and LLNCOPDVC as FEV1/VC below the LLN using the maximum value of FVC or SVC. Results: Prevalence of GOLDCOPD(FVC) was 10.0% (95% confidence interval [CI] 8.2-12.0) and the prevalence of LLNCOPDFVC was 9.5% (95% CI 7.8-11.4). When estimates were based on VC, the prevalence became higher; 16.4% (95% CI 14.3-18.9) and 15.6% (95% CI 13.5-17.9) for GOLDCOPD(VC) and LLNCOPDVC, respectively. The group of additional subjects classified as having COPD based on VC, had lower FEV1, more wheeze and higher residual volume compared to subjects without any COPD. Conclusion: The prevalence of COPD was significantly higher when the ratio FEV1/VC was calculated using the highest value of SVC or FVC compared with using FVC only. Subjects classified as having COPD when using the VC concept were more obstructive and with indications of air trapping. Hence, the use of only FVC when assessing airflow limitation may result in a considerable under diagnosis of subjects with mild COPD.

Place, publisher, year, edition, pages
2016. Vol. 11, 927-933 p.
Keyword [en]
obstructive, epidemiology, general population, air trapping, spirometry, slow vital capacity, asthma
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-297564DOI: 10.2147/COPD.S104644ISI: 000375178100001PubMedID: 27194908OAI: oai:DiVA.org:uu-297564DiVA: diva2:942322
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVINNOVAForte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2016-06-23 Created: 2016-06-23 Last updated: 2016-06-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindberg, EvaMalinovschi, AndreiJanson, Christer
By organisation
Department of Medical SciencesClinical Physiology
In the same journal
The International Journal of Chronic Obstructive Pulmonary Disease
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 34 hits
ReferencesLink to record
Permanent link

Direct link