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Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Molecular Imaging.
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2016 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 59, no 9, 1968-1972 p.Article in journal (Refereed) Published
Abstract [en]

AIMS/HYPOTHESIS: The aim of this study was to investigate pancreatic perfusion and its response to a glucose load in patients with type 1 diabetes mellitus compared with non-diabetic ('healthy') individuals.

METHODS: Eight individuals with longstanding type 1 diabetes and ten sex-, age- and BMI-matched healthy controls underwent dynamic positron emission tomography scanning with (15)O-labelled water before and after intravenous administration of glucose. Perfusion in the pancreas was measured. Portal and arterial hepatic perfusion were recorded as references.

RESULTS: Under fasting conditions, total pancreatic perfusion was on average 23% lower in the individuals with diabetes compared with healthy individuals. Glucose increased total pancreatic and portal hepatic blood perfusion in healthy individuals by 48% and 38%, respectively. In individuals with diabetes there was no significant increase in either total pancreatic or portal hepatic perfusion.

CONCLUSIONS/INTERPRETATION: Individuals with type 1 diabetes have reduced basal pancreatic perfusion and a severely impaired pancreatic and splanchnic perfusion response to intravenous glucose stimulation.

Place, publisher, year, edition, pages
2016. Vol. 59, no 9, 1968-1972 p.
Keyword [en]
Blood flow; Glucose; Pancreas; Pancreatic islets; Perfusion; Type 1 diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-297684DOI: 10.1007/s00125-016-4016-2ISI: 000380668800021PubMedID: 27306617OAI: oai:DiVA.org:uu-297684DiVA: diva2:942967
Funder
Swedish Research Council, K2013-55-X-15043-10-5 K2015-54X-12219-19-4 K2013-64X-08268-26-3Swedish Diabetes AssociationSwedish Child Diabetes FoundationNovo Nordisk
Note

De 2 sista författarna delar sistaförfattarskapet

Available from: 2016-06-27 Created: 2016-06-27 Last updated: 2016-09-15Bibliographically approved

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Carlbom, LinaEspes, DanielLubberink, MarkEriksson, OlofJohansson, LarsJansson, LeifKorsgren, OlleAhlström, HåkanCarlsson, Per-Ola
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RadiologyDepartment of Medical Cell BiologyDivision of Molecular ImagingClinical ImmunologyTransplantation and regenerative medicine
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