Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes
2016 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 59, no 9, 1968-1972 p.Article in journal (Refereed) Published
AIMS/HYPOTHESIS: The aim of this study was to investigate pancreatic perfusion and its response to a glucose load in patients with type 1 diabetes mellitus compared with non-diabetic ('healthy') individuals.
METHODS: Eight individuals with longstanding type 1 diabetes and ten sex-, age- and BMI-matched healthy controls underwent dynamic positron emission tomography scanning with (15)O-labelled water before and after intravenous administration of glucose. Perfusion in the pancreas was measured. Portal and arterial hepatic perfusion were recorded as references.
RESULTS: Under fasting conditions, total pancreatic perfusion was on average 23% lower in the individuals with diabetes compared with healthy individuals. Glucose increased total pancreatic and portal hepatic blood perfusion in healthy individuals by 48% and 38%, respectively. In individuals with diabetes there was no significant increase in either total pancreatic or portal hepatic perfusion.
CONCLUSIONS/INTERPRETATION: Individuals with type 1 diabetes have reduced basal pancreatic perfusion and a severely impaired pancreatic and splanchnic perfusion response to intravenous glucose stimulation.
Place, publisher, year, edition, pages
2016. Vol. 59, no 9, 1968-1972 p.
Blood flow; Glucose; Pancreas; Pancreatic islets; Perfusion; Type 1 diabetes
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:uu:diva-297684DOI: 10.1007/s00125-016-4016-2ISI: 000380668800021PubMedID: 27306617OAI: oai:DiVA.org:uu-297684DiVA: diva2:942967
FunderSwedish Research Council, K2013-55-X-15043-10-5 K2015-54X-12219-19-4 K2013-64X-08268-26-3Swedish Diabetes AssociationSwedish Child Diabetes FoundationNovo Nordisk
De 2 sista författarna delar sistaförfattarskapet2016-06-272016-06-272016-09-15Bibliographically approved