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Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Bangor Univ, Sch Chem, Bangor LL57 2DG, Gwynedd, Wales.
Univ Liverpool, Inst Translat Med, Dept Cellular & Mol Physiol, Liverpool L69 3BX, Merseyside, England.
Johannes Gutenberg Univ Mainz, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Fed Rio Grande do Norte, UFRN, Inst Brain, Natal, RN, Brazil.ORCID iD: 0000-0002-0066-8217
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2016 (English)In: Pharmacological Research, ISSN 1043-6618, E-ISSN 1096-1186, Vol. 111, 290-302 p.Article in journal (Refereed) Published
Abstract [en]

Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and due to lower side effects. In this review, we discuss the application of network pharmacology for cancer drug discovery. We provide an overview of the current state of knowledge on network pharmacology, focus on different technical approaches and implications for cancer therapy (e.g. polypharmacology and synthetic lethality), and illustrate the therapeutic potential with selected examples green tea polyphenolics, Eleutherococcus senticosus, Rhodiola rosea, and Schisandra chinensis). Finally, we present future perspectives on their plausible applications for diagnosis and therapy of cancer.

Place, publisher, year, edition, pages
2016. Vol. 111, 290-302 p.
Keyword [en]
Eleutherococcus senticosus; Genomics; Green tea polyphenolics; Lithospermum erythrorhizon; Metabolomics; Polypharmacology; Proteomics; Rhodiola rosea; Schisandra chinensis; Synthetic lethality; Systems biology; Transcriptomics
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-297685DOI: 10.1016/j.phrs.2016.06.018ISI: 000384784000029PubMedID: 27329331OAI: oai:DiVA.org:uu-297685DiVA: diva2:942995
Available from: 2016-06-27 Created: 2016-06-27 Last updated: 2016-12-05Bibliographically approved

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