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Genetic differentiation within and away from the chromosomal rearrangements characterising hybridising chromosomal races of the western house mouse (Mus musculus domesticus)
Univ York, Dept Biol, Wentworth Way, York YO10 5DD, N Yorkshire, England.;Leibniz Inst Zoo & Wildlife Res, Dept Evolutionary Genet, Alfred Kowalke Str 17, D-10315 Berlin, Germany..
Univ York, Dept Biol, Wentworth Way, York YO10 5DD, N Yorkshire, England.;Fera Sci, York YO41 1LZ, N Yorkshire, England..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics. Univ York, Dept Biol, Wentworth Way, York YO10 5DD, N Yorkshire, England.;Cornell Univ, Dept Ecol & Evolut, Corson Hall, Ithaca, NY 14853 USA..
Univ York, Dept Biol, Wentworth Way, York YO10 5DD, N Yorkshire, England.;Univ Lisbon, Fac Ciencias, Dept Biol Anim, CESAM Ctr Environm & Marine Studies, P-1749016 Lisbon, Portugal..
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2016 (English)In: Chromosome Research, ISSN 0967-3849, E-ISSN 1573-6849, Vol. 24, no 2, 271-280 p.Article in journal (Refereed) PublishedText
Abstract [en]

The importance of chromosomal rearrangements for speciation can be inferred from studies of genetic exchange between hybridising chromosomal races within species. Reduced fertility or recombination suppression in karyotypic hybrids has the potential to maintain or promote genetic differentiation in genomic regions near rearrangement breakpoints. We studied genetic exchange between two hybridising groups of chromosomal races of house mouse in Upper Valtellina (Lombardy, Italy), using microsatellites. These groups differ by Robertsonian fusions and/or whole-arm reciprocal translocations such that F-1 hybrids have a chain-of-five meiotic configuration. Previous studies showed genetic differentiation in two chromosomes in the chain-of-five (10 and 12) close to their centromeres (i.e. the rearrangement breakpoints); we have shown here that the centromeric regions of the other two chromosomes in the chain (2 and 8) are similarly differentiated. The internal chromosomes of the chain (8 and 12) show the greatest differentiation, which may reflect pairing and recombination properties of internal and external elements in a meiotic chain. Importantly, we found that centromeric regions of some non-rearranged chromosomes also showed genetic differentiation between the hybridising groups, indicating a complex interplay between chromosomal rearrangements and other parts of the genome in maintaining or promoting differentiation and potentially driving speciation between chromosomal races.

Place, publisher, year, edition, pages
2016. Vol. 24, no 2, 271-280 p.
Keyword [en]
chromosomal hybrid zone, introgression, microsatellites, Robertsonian fusion, speciation
National Category
Biochemistry and Molecular Biology Genetics
URN: urn:nbn:se:uu:diva-297806DOI: 10.1007/s10577-016-9520-1ISI: 000375710800010PubMedID: 27048372OAI: oai:DiVA.org:uu-297806DiVA: diva2:943499
Available from: 2016-06-28 Created: 2016-06-28 Last updated: 2016-06-28Bibliographically approved

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