Localization of histamine (H-1, H-2, H-3 and H-4) receptors in mouse inner ear
2016 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, no 6, 537-544 p.Article in journal (Refereed) PublishedText
Conclusion: The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear.
Objective: To analyse the presence of histamine receptors in the normal mouse inner ear.
Methods: CBA/J mice were used in this study. The localization of H1R, H2R, H3R, and H4R in the inner ear, i.e. cochlea, vestibular end organs, vestibular ganglion, and endolymphatic sac, was studied by real-time PCR and immunohistochemistry.
Results: The mRNA for each receptor sub-type was detected in the inner ear. In the immunohistochemical study, the organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory epithelium, and endolymphatic sac cells showed an immunofluorescent reaction to all histamine receptors.
Place, publisher, year, edition, pages
2016. Vol. 136, no 6, 537-544 p.
Histamine, histamine receptor, inner ear, mouse, RT-PCR, immunohistochemistry
IdentifiersURN: urn:nbn:se:uu:diva-297250DOI: 10.3109/00016489.2015.1136433ISI: 000375483400001PubMedID: 26854127OAI: oai:DiVA.org:uu-297250DiVA: diva2:944224