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The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels
Univ Hosp Verona, Unit Occupat Med, Verona, Italy..
Inst Epidemiol I, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Univ Munich, Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany..
Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth, Sect Environm Occupat & Hlth, Aarhus, Denmark..
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;Hosp del Mar, Med Res Inst, IMIM, Barcelona, Spain.;UPF, Barcelona, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain..
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2016 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 71, no 6, 859-868 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: The relation between IgE sensitization and allergic respiratory symptoms has usually been evaluated by dichotomizing specific IgE levels. The aim of this study was to evaluate the association between specific IgE levels and risk of symptoms on allergen-related exposure, with special reference to allergen-related asthma-rhinitis comorbidity.

Methods: We considered 6391 subjects enrolled within the European Community Respiratory Health Survey 2, having information on cat/grass/D. pteronyssinus IgE levels and symptoms on exposure to animals/pollen/dust. The risk of oculonasal/asthmalike/both symptoms was evaluated by a multinomial logistic model.

Results: A clear positive association was observed between specific IgE levels to cat/grass/mite and the risk of symptoms on each allergen-related exposure (test for trend with P < 0.001). This trend was particularly pronounced when considering the coexistence of asthmalike and oculonasal symptoms. Compared to nonsensitized subjects, subjects with specific IgE to cat >= 3.5 kU/l presented relative risk ratios of 11.4 (95% CI 6.7-19.2), 18.8 (8.2-42.8), and 55.3 (30.5-100.2) when considering, respectively, only oculonasal symptoms, only asthmalike symptoms, or both. A similar pattern was observed when considering specific IgE to grass/mite and symptoms on exposure to pollen/dust. Also the proportion of people using inhaled medicines or visiting a general practitioner for breathing problems in the previous year increased with increasing sum of specific IgE to cat/grass/mite.

Conclusion: Specific IgE level is the most important predictor of allergen-related symptoms. The risk of both oculonasal/asthmalike symptoms increases with specific IgE levels, suggesting that specific IgE contributes to the 'united airways disease'.

Place, publisher, year, edition, pages
2016. Vol. 71, no 6, 859-868 p.
Keyword [en]
allergen exposure, allergic respiratory symptoms, specific IgE levels, united airways disease
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-298058DOI: 10.1111/all.12841ISI: 000376148100012PubMedID: 26764559OAI: oai:DiVA.org:uu-298058DiVA: diva2:944929
Note

Funding: The coordination of the ECRHS II was supported by the European Commission, as part of its Quality of Life program. Funding for the individual centers is listed at http://www.ecrhs.org. The funding sources had no role in the design and conduct of the study.

Available from: 2016-06-30 Created: 2016-06-29 Last updated: 2016-06-30Bibliographically approved

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