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Diamondoid-functionalized gold nanogaps as sensors for natural, mutated, and epigenetically modified DNA nucleotides
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. UFF, ICEx, Dept Fis, Volta Redonda, RJ, Brazil..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
2016 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 8, no 19, 10105-10112 p.Article in journal (Refereed) PublishedText
Abstract [en]

Modified tiny hydrogen-terminated diamond structures, known as diamondoids, show a high efficiency in sensing DNA molecules. These diamond cages, as recently proposed, could offer functionalization possibilities for gold junction electrodes. In this investigation, we report on diamondoid-functionalized electrodes, showing that such a device would have a high potential in sensing and sequencing DNA. The smallest diamondoid including an amine modification was chosen for the functionalization. Here, we report on the quantum tunneling signals across diamondoid-functionalized Au(111) electrodes. Our work is based on quantum-transport calculations and predicts the expected signals arising from different DNA units within the break junctions. Different gating voltages are proposed in order to tune the sensitivity of the functionalized electrodes with respect to specific nucleotides. The relation of this sensitivity to the coupling or decoupling of the electrodes is discussed. Our results also shed light on the sensing capability of such a device in distinguishing the DNA nucleotides, in their natural and mutated forms.

Place, publisher, year, edition, pages
2016. Vol. 8, no 19, 10105-10112 p.
National Category
Materials Chemistry Nano Technology
Identifiers
URN: urn:nbn:se:uu:diva-298261DOI: 10.1039/c6nr00500dISI: 000376047200023PubMedID: 27121677OAI: oai:DiVA.org:uu-298261DiVA: diva2:945284
Funder
German Research Foundation (DFG), SFB 716German Research Foundation (DFG)Carl Tryggers foundation Swedish Research Council, 621-2009-3628
Available from: 2016-07-01 Created: 2016-07-01 Last updated: 2016-07-01Bibliographically approved

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