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Learning and sleep-dependent consolidation of spatial and procedural memories are unaltered in young men under a fixed short sleep schedule
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
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2016 (English)In: Neurobiology of Learning and Memory, ISSN 1074-7427, E-ISSN 1095-9564, Vol. 131, 87-94 p.Article in journal (Refereed) Published
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Abstract [en]

Objective: To investigate if a fixed short sleep schedule impairs one of the main functions of sleep, which is to consolidate newly learned memories. Methods: Sixteen young men participated in two experimental conditions, each of which lasted for 3 consecutive days and nights in our laboratory: a short sleep schedule (4.25-h sleep opportunity per night) versus a normal sleep schedule (8.5 h per night). In the evening after two experimental nights, participants learned locations of 15 card pairs (spatial memory task) and a procedural finger tapping sequence task. Post-sleep retrieval of both memory tasks was tested the next morning. Results: The short sleep schedule, compared with the normal sleep schedule, considerably altered sleep characteristics, e.g. the proportion of time in slow-wave sleep increased across the three experimental nights. In contrast, neither learning in the evening of day 2, nor subsequent overnight memory consolidation (i.e. concerning the change in memory performance between pre-sleep learning on day 2 and post sleep retrieval on day 3) differed between the normal and short sleep schedule conditions. Conclusions: Our findings suggest that learning in the evening and subsequent sleep-dependent consolidation of procedural and spatial memories are unaltered in young men living under a fixed short sleep schedule. Future studies are warranted to validate our findings in other groups (e.g. adolescents and older subjects) and after more prolonged chronic sleep loss paradigms.

Place, publisher, year, edition, pages
2016. Vol. 131, 87-94 p.
Keyword [en]
Sleep-dependent memory consolidation, Procedural memory, Spatial memory, Sleep duration
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-298243DOI: 10.1016/j.nlm.2016.03.012ISI: 000376224900011PubMedID: 26995308OAI: oai:DiVA.org:uu-298243DiVA: diva2:945555
Funder
AFA InsuranceLars Hierta Memorial FoundationNovo NordiskThe Swedish Brain FoundationSwedish Society for Medical Research (SSMF)Swedish Research CouncilÅke Wiberg Foundation
Available from: 2016-07-01 Created: 2016-07-01 Last updated: 2017-11-28Bibliographically approved

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Cedernaes, JonathanBroman, Jan-ErikSchiöth, Helgi B.Benedict, Christian

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