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Conformational stability of adsorbed insulin studied with mass spectrometry and hydrogen exchange
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1999 (English)In: ANALYTICAL CHEMISTRY, ISSN 0003-2700, Vol. 71, no 15, 3219-3225 p.Article in journal (Other scientific) Published
Abstract [en]

A new method is described for direct monitoring of the conformational stability of proteins that are physically adsorbed from solution onto a solid substrate. The adsorption-induced conformational changes of insulin are studied using a combination of hydr

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 1999. Vol. 71, no 15, 3219-3225 p.
Keyword [en]
LASER-DESORPTION IONIZATION; SOLID-SURFACES; ADSORPTION-KINETICS; PROTEINS; DESORPTION/IONIZATION; REFLECTOMETRY; SPECTROSCOPY; PROINSULIN; INTERFACES; ASSIGNMENT
Identifiers
URN: urn:nbn:se:uu:diva-66764OAI: oai:DiVA.org:uu-66764DiVA: diva2:94675
Note
Addresses: Buijs J, Univ Uppsala, Div Ion Phys, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden. Univ Uppsala, Div Ion Phys, Angstrom Lab, S-75121 Uppsala, Sweden. Escuela Politecn Nacl, Dept Phys, Quito, Ecuador. Malardalen Univ, Dept Chem Engn, S-63105 EAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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