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Investigation of the regulation of the rhs locus in Salmonella enterica serovar Typhimurium
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The rearrangement hotspot (rhs) loci were discovered over thirty years ago, but it was only

recently that the Rhs proteins were found to have the capacity to mediate Contact-Dependent

growth Inhibition (CDI) of related bacterial species. However, the regulation of the rhs loci

has been poorly understood. In this study the regulation of the rhs locus in the pathogen

Salmonella enterica serovar Typhimurium (S.tm.) was investigated in infection-relevant

conditions. A set of plasmid transcriptional fusions of different rhs promoters to YFP was

used to analyse the activities of the promoters in wild type and in S.tm. regulatory mutants. An

internal rhs transcript was shown to be expressed and at different levels within the bacterial

population. Furthermore, it was found to be regulated by the virulence factors RpoS and HilD.

Place, publisher, year, edition, pages
UPTEC X, 16 017
National Category
URN: urn:nbn:se:uu:diva-298730OAI: oai:DiVA.org:uu-298730DiVA: diva2:946953
Educational program
Molecular Biotechnology Engineering Programme
Available from: 2016-07-06 Created: 2016-07-06 Last updated: 2016-07-06Bibliographically approved

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The full text will be freely available from 2018-07-01 13:19
Available from 2018-07-01 13:19

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