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Lymphatic System in Cardiovascular Medicine
Univ Helsinki, Wihuri Res Inst, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland.;Univ Helsinki, Translat Canc Biol Program, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland..
Univ Helsinki, Wihuri Res Inst, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland.;Univ Helsinki, Translat Canc Biol Program, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland..
Univ Helsinki, Wihuri Res Inst, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
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2016 (English)In: Circulation Research, ISSN 0009-7330, E-ISSN 1524-4571, Vol. 118, no 3, 515-530 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation. The cardinal manifestation of lymphatic malfunction is lymphedema. Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular diseases including obesity and metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction. Here, we review the most recent advances in the field of lymphatic vascular biology, with a focus on cardiovascular disease.

Place, publisher, year, edition, pages
2016. Vol. 118, no 3, 515-530 p.
Keyword [en]
cardiovascular diseases, lymphangiogenesis, vascular endothelial growth factor C, vascular endothelial growth factor receptor-3, endothelial cells
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-294816DOI: 10.1161/CIRCRESAHA.115.306544ISI: 000371014400017PubMedID: 26846644OAI: oai:DiVA.org:uu-294816DiVA: diva2:947312
Available from: 2016-07-07 Created: 2016-05-27 Last updated: 2016-07-07Bibliographically approved

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