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Mechanisms of action of bone morphogenetic proteins in cancer
Univ Oxford, Wellcome Trust Ctr Human Genet, Gastrointestinal Stem Cell Biol Lab, Oxford, England..
Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Tokyo, Japan..
Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Tokyo, Japan..
Ehime Univ, Grad Sch Med, Dept Mol Med Pathogenesis, Matsuyama, Ehime 790, Japan.;Uppsala Univ, Biomed Ctr, Sci Life Lab, Ludwig Inst Canc Res, Box 595, S-75124 Uppsala, Sweden..
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2016 (English)In: Cytokine & growth factor reviews, ISSN 1359-6101, E-ISSN 1879-0305, Vol. 27, 81-92 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

The bone morphogenetic proteins (BMPs) play fundamental roles in embryonic development and control differentiation of a diverse set of cell types. It is therefore of no surprise that the BMPs also contribute to the process of tumourigenesis and regulate cancer progression through various stages. We summarise here key roles of BMP ligands, receptors, their signalling mediators, mainly focusing on proteins of the Smad family, and extracellular antagonists, that contribute to the onset of tumourigenesis and to cancer progression in diverse tissues. Overall, the BMP pathways seem to act as tumour suppressors that maintain physiological tissue homeostasis and which are perturbed in cancer either via genetic mutation or via epigenetic misregulation of key gene components. BMPs also control the self-renewal and fate choices made by stem cells in several tissues. By promoting cell differentiation, including inhibition of the process of epithelial-mesenchymal transition, BMPs contribute to the malignant progression of cancer at advanced stages. It is therefore reasonable that pharmaceutical industries continuously develop biological agents and chemical modulators of BMP signalling with the aim to improve therapeutic regimes against several types of cancer.

Place, publisher, year, edition, pages
2016. Vol. 27, 81-92 p.
Keyword [en]
BMP, Cancer, EMT, Metastasis, TGF-beta
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-294817DOI: 10.1016/j.cytogfr.2015.11.009ISI: 000371371200007PubMedID: 26678814OAI: oai:DiVA.org:uu-294817DiVA: diva2:947315
Available from: 2016-07-07 Created: 2016-05-27 Last updated: 2016-07-07Bibliographically approved

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Moustakas, Aristidis
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Department of Medical Biochemistry and MicrobiologyLudwig Institute for Cancer ResearchScience for Life Laboratory, SciLifeLab
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