Red-cell trapping in the rat renal microcirculation induced by low-osmolar contrast media and mannitol
1993 (English)In: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 28, no 11, 1033-1038 p.Article in journal (Refereed) Published
RATIONALE AND OBJECTIVES: In acute renal failure after ischemia, intravascular obstruction by trapped red blood cells in the microvasculature of the renal outer medulla is a consistent finding. The influence of intravenously injected contrast media (CM) on such obstruction was investigated. METHODS: Anesthetized rats were subjected to 45 minutes of unilateral renal ischemia. Red-cell trapping in ischemically injured kidneys and in the contralateral uninjured kidneys was estimated from the intrarenal distribution of 51Cr-labelled erythrocytes after injection of ioxaglate or iopamidol in a dose of 1,600 mg I/kg body weight. As an osmolar control substance, mannitol (950 mOsm/kg) was given to a third group and isotonic Ringer's solution was administered to a fourth group. RESULTS: In the uninjured kidneys, treatment with ioxaglate or mannitol resulted in no red-cell trapping, while the iopamidol-treated group showed red-cell trapping in the inner stripe of the outer medulla in a dose-dependent manner. In the ischemically injured kidneys, both CM and mannitol enhanced the red-cell trapping in the inner stripe of the renal medulla. CONCLUSION: The results indicate that intravenously administered ioxaglate and iopamidol enhance the microvascular obstructions evoked by ischemic injury and that iopamidol may induce local impairment in renal medullary microcirculation in a normal kidney.
Place, publisher, year, edition, pages
1993. Vol. 28, no 11, 1033-1038 p.
Animals, Dose-Response Relationship; Drug, Erythrocyte Volume/drug effects, Erythrocytes/*drug effects, Iopamidol/*pharmacology, Ioxaglic Acid/*pharmacology, Ischemia/*physiopathology, Kidney/*blood supply, Male, Mannitol/*pharmacology, Microcirculation, Rats, Rats; Sprague-Dawley
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-66911PubMedID: 8276574OAI: oai:DiVA.org:uu-66911DiVA: diva2:94822