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Red-cell trapping in the rat renal microcirculation induced by low-osmolar contrast media and mannitol
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
1993 (English)In: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 28, no 11, 1033-1038 p.Article in journal (Refereed) Published
Abstract [en]

RATIONALE AND OBJECTIVES: In acute renal failure after ischemia, intravascular obstruction by trapped red blood cells in the microvasculature of the renal outer medulla is a consistent finding. The influence of intravenously injected contrast media (CM) on such obstruction was investigated. METHODS: Anesthetized rats were subjected to 45 minutes of unilateral renal ischemia. Red-cell trapping in ischemically injured kidneys and in the contralateral uninjured kidneys was estimated from the intrarenal distribution of 51Cr-labelled erythrocytes after injection of ioxaglate or iopamidol in a dose of 1,600 mg I/kg body weight. As an osmolar control substance, mannitol (950 mOsm/kg) was given to a third group and isotonic Ringer's solution was administered to a fourth group. RESULTS: In the uninjured kidneys, treatment with ioxaglate or mannitol resulted in no red-cell trapping, while the iopamidol-treated group showed red-cell trapping in the inner stripe of the outer medulla in a dose-dependent manner. In the ischemically injured kidneys, both CM and mannitol enhanced the red-cell trapping in the inner stripe of the renal medulla. CONCLUSION: The results indicate that intravenously administered ioxaglate and iopamidol enhance the microvascular obstructions evoked by ischemic injury and that iopamidol may induce local impairment in renal medullary microcirculation in a normal kidney.

Place, publisher, year, edition, pages
1993. Vol. 28, no 11, 1033-1038 p.
Keyword [en]
Animals, Dose-Response Relationship; Drug, Erythrocyte Volume/drug effects, Erythrocytes/*drug effects, Iopamidol/*pharmacology, Ioxaglic Acid/*pharmacology, Ischemia/*physiopathology, Kidney/*blood supply, Male, Mannitol/*pharmacology, Microcirculation, Rats, Rats; Sprague-Dawley
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-66911PubMedID: 8276574OAI: oai:DiVA.org:uu-66911DiVA: diva2:94822
Available from: 2004-09-23 Created: 2004-09-23 Last updated: 2017-11-28Bibliographically approved

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Nygren, AHellberg, OHansell, P

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